library of C++ functions that support applications of Stan in Pharmacometrics

Population Experimental Design (PopED) in R

Chi is an open source Python package which is designed for PKPD modelling and model-informed precision dosing (MIPD).

R package for using ubiquity

PySB add-on providing domain-specific macros and models for empirical and mechanistic PK/PD modeling.

Create diagrams with ggplot.

Physiology-based systems pharmacology model of thyroid hormones regulation in rat and human

How to cite: Van De Vyver, A.J., Eigenmann, M.J., Ovacik, M., Pöhl, C., Herter, S., Weinzierl, T., Fauti, T., Klein, C., Lehr, T., Bacac, M., Walz, A.-C. (2021). A novel approach for quantifying the pharmacological activity of T cell engagers utilizing in vitro time course experiments and streamlined data analysis. AAPS

ODE-based quantitative systems pharmacology model of B cell depletion and repopulation under anti-CD20 therapy (rituximab, ocrelizumab). Multi-compartment PK/PD with Bayesian parameter estimation, uncertainty quantification, and posterior predictive validation. Python · PyMC · scipy · MLflow.

Python-first toolkit for dissolution similarity, NCA, PK/PD simulation, and pharmacometric reporting

PK/PD clinical trial simulator with virtual patients, adaptive randomization, external-control borrowing, and protocol optimization.

Open Python Web App for Pharmcological Modeling and Analysis

An MCP server providing AI assistants with access to MATLAB SimBiology for modelling, simulating, and analyzing biological systems

A curated, tier-annotated dataset and simulation engine of tumor-growth-inhibition (TGI) and exposure-response models that quantifies model-selection risk in oncology drug development, exported directly into standard pharmacometric and systems-biology formats like NONMEM, SBML, and rxode2.

Multi-analyte ADC PK/PD and exposure-driven dose selection — therapeutic window and OBD from conjugate efficacy vs. free-payload toxicity, the toxicology paradigm (not MABEL).

Reproducibility-first mechanistic biology research stack: CFM (SCNT feasibility), BSE (virtual PK/PD physiology), and NSCS (closed-loop equation discovery).

Physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model of canagliflozin

Interactive PK/PD simulator for 18 hospital antimicrobials — educational tool for dose optimization

Mechanistic molecule→parasite-exposure→function→phenotype engine for P. falciparum (open-source)

R client to the Rx Studio APIs.